Ethylenediamine-1,1,2,2-D4 Dihydrochloride is a high-purity, deuterium-labeled compound widely used in analytical chemistry, pharmaceutical research, and isotopic studies. This compound is the deuterated form of ethylenediamine dihydrochloride, where all four hydrogens on the ethylenediamine backbone are replaced by deuterium (D).
Researchers choose Ethylenediamine-1,1,2,2-D4 Dihydrochloride for its superior performance as an internal standard in mass spectrometry (MS) and as a stable isotope tracer in metabolic and pharmacokinetic studies.
Chemical Name: Ethylenediamine-1,1,2,2-D4 Dihydrochloride
Synonyms: EDA-d4·2HCl, [²H₄]-ethane-1,2-diamine dihydrochloride
Molecular Formula: C₂H₄D₄N₂·2HCl
Molecular Weight: ~132.1 g/mol
Isotopic Labeling: Deuterium substitution at all four hydrogens
Ethylenediamine-1,1,2,2-D4 Dihydrochloride is essential for:
Mass Spectrometry (LC-MS/MS, GC-MS):
Acts as an internal standard for precise quantification.
NMR Spectroscopy:
Deuterium substitution minimizes background interference.
Metabolomics & Tracer Studies:
Tracks amine pathways and biological transformations.
Pharmaceutical & Drug Research:
Used in drug metabolism, stability, and bioavailability studies.
Appearance: White crystalline powder
Solubility: Soluble in water and ethanol
Stability: Stable under normal laboratory conditions; hygroscopic
Storage: Store at 2–8 °C, dry and protected from light
Like most laboratory chemicals, Ethylenediamine-1,1,2,2-D4 Dihydrochloride should be handled with care:
Hazards: May cause skin, eye, or respiratory irritation
Precautions: Use gloves, goggles, and protective clothing
Disposal: Follow standard laboratory chemical waste protocols
Ethylenediamine-1,1,2,2-D4 Dihydrochloride is trusted by researchers worldwide due to its:
High isotopic purity
Consistent quality for reproducible results
Compatibility with advanced analytical instruments
Essential role in isotope labeling and tracer studies